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Lamivudine (Ii',Tercet'-dideoxy-Three'-thiacytidine, 3TC) is a potent reverse transcriptase inhibitor. It might inhibit two types (One & Two) of HIV reverse transcriptase and as well a reverse transcriptase of hepatitis B. It needs to exist as phosphorylated to its triphosphate form prior to these are active. 3TC-triphosphate as well inhibits cellular DNA polymerase.

Lamivudine is administered orally, & these are speedily absorbed using the bio-availability of on top 80%. A few search suggests that 3tc might cross a blood-brain barrier. Lamivudine is typically given inside combination by having zidovudine, with which these are extremely synergetic. Lamivudine professional assistance has been shown to restore azt sensitivity of antecedently immune HIV. Many mutagenicity tests indicate that 3tc should non indicate mutagenic activity in therapeutic drugs.

Lamivudine has been utilized for coarse of action of chronic hepatitis B at the lower dose that utilize within HIV. It improves a seroconversion of e-antigen caring hepatitis B & as well improve histology staging of the liver. Long term have of 3tc regrettably leads to emergence of the immune hepatitis B virus (YMDD) mutant. Despite this, 3tc is however utilized widely when these are swell tolerated.

History
Lamivudine was invented by Bernard Belleau and Nghe Nguyen-Ba at the Quebec-depending BioChem Pharma around 1989. the drug was late licensed to the British drug company Glaxo for a 14 percent royalty.

Lamivudine
a.k.a. 3TC, Epivir.

Lamivudine (3TC)
An antiretroviral (anti-HIV) agent, which belongs to a class of drugs called nucleoside analogue reverse transcriptase inhibitors.

Combivir
Lamivudine and zidovudine. Features product and prescribing information for US consumers and healthcare professionals.

Epivir
Product information for US residents in PDF format. [Acrobat Reader required]

Epivir HBV
Product information for US residents in PDF format. [Acrobat Reader required]

Lamivudine
(Epivir, 3TC)

Zeffix UK
GlaxoSmithKline prescribing information for UK residents.

DrugDigest: Lamivudine
Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available. Sold under brand names such as: 3TC, Epivir, and Epivir-HBV.

Combivir
Full prescribing information from RxList.

Lamivudine - Familydoctor.org
Information for patients in English and Spanish.